Objective
The primary aim was to systematically review the effectiveness and safety of pharmacological or non-pharmacological interventions used to prevent or treat platinum-induced ototoxicity in adult cancer patients. Even though ototoxicity is a less common adverse effect of other chemotherapy agents, we consider that studies could report ototoxicity interventions for multiple chemotherapy regimens. So our secondary aim was to assess pharmacological or non-pharmacological interventions for ototoxicity caused by other chemotherapy agents in adult cancer patients.