FIGURE LEGEND: Improved monoclonal antibody neutralization for Omicron sublineages BA.2.75, BF.7 and BQ.1

(A) A comparison of 14 globally most prevalent Omicron sublineages for their respective positions in the RBD region. The location of mutations in the RBD region of spike proteins of SARS-CoV-2 lineages is indicated in blue. RBD residues that interact with ACE2 are indicated in orange. Monoclonal antibodies (mAbs) targeting the epitope at RBD positions are indicated in red.

(B) A comparison of Omicron sublineages for only RBD residues interacting with ACE2 against mAbs. RBD residues that interact with ACE2 have been identified for 17 positions, out of which eight positions, as indicated in yellow, had mutations reported across Omicron sublineages, and nine positions, as indicated in green, had no mutations.