Author contributions
E.C. and R.T. designed the study; M.A. assisted with bioinformatic analysis; R.T. provided funding; A.R., I.P., M.Q., U.L., H.B., U.S., C.L., P.B., A.Ö., B.Ö., and V.L. provided samples and associated biological information; E.C. performed laboratory work, executed bioinformatic analyses and analyzed the data; E.C. and R.T. interpreted the results, E.C. wrote the draft manuscript with input from R.T and M.A. All authors edited and approved the final manuscript.