What this study adds
- Overexpression of Lf in astrocytes reduced Aβ burden via inhibiting Aβ
production.
- The PP2A activity was modulated by the p38 activation-mediated
interaction of p38 and PP2Ac.
- Astrocytes could secrete Lf to neurons to stimulate p38 activation by
targeting LRP1, and finally promoting PP2A-mediated dephosphorylation
of APP.