Title: Mononeuropathy Multiplex as An Uncommon Presentation of Intravascular Lymphoma: A Case Report
Bahram Haqi-Ashtiani 1, Parichehr Moghaddam2, Farzaneh Barzkar 3, Ali Zare Mehrjerdi4, Mostafa Almasi-Dooghaee 5 *
1 MD, Assistant professor, Firoozgar hospital, Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Email: bhaghi2000@yahoo.com
2 MD, Firoozgar hospital, Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Email: parichehr.moghaddam@gmail.com
3 MD, Center for Educational Research in Medical Sciences(CERMS), School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Email: barzkarfarzane@gmail.com
4 MD, Associate Professor of Pathology, Firoozgar Clinical Research Development Center (FCRDC), Department of Pathology, Iran University of Medical Sciences, Tehran, Iran. Email: azaremehrjardi@yahoo.com
5 MD, Assistant professor, Firoozgar hospital, Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Email: a_mostafa108@yahoo.com
* Corresponding author: Mostafa Almasi-Dooghaee
Address: Neurology department, Firoozgar hospital, Valadi St., Valiasr Ave., Tehran, Iran
email: a_mostafa108@yahoo.com
Tel: +98 21 82141817

List of abbreviations:

MM: Multiple Mononeuropathy
ONLS: Overall neuropathy limitations scale
IVLBCL: Intravascular large B-cell lymphoma
IVL: Intravascular lymphoma
Abstract:
Case Presentation: A 64-year-old man presented with asymmetric paresthesia and subsequent weakness of his feet and a 10-kg weight loss over 40 days. Electrodiagnostic studies revealed distal axonal sensory-motor polyneuropathy with ongoing axonal loss. A peroneal nerve biopsy showed intravascular proliferation of CD-20 positive lymphocytes, which suggested intravascular large B-cell lymphoma.
Clinical Message: Although intravascular lymphoma rarely presents with peripheral neuropathy, learning about this presentation can lead to timely diagnosis and improved prognosis in patients with intravascular lymphoma.