Kasper 2014
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Period 1 intervention:
High dose pregabalin
n = 206
Low dose pregabalin
n = 206
Placebo groups
n = N/A
Period 2 intervention:
High dose pregabalin
n = 121
Low dose pregabalin
n = 112
Placebo groups
n = 77
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Gabapentinoid use
Intervention: 117/233 discontinued the pregabalin intervention (50.2%)
Control: 51/77 completed the placebo intervention (66.2%)
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High dose n = 121
Low dose n = 121
Placebo n = NR
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High dose n = 27/154
Low dose n = 21 (plus one unrelated death)/154
Placebo n = NR
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Improved (HAM-A)
High dose group:
-18.7 (95%CI -20.0 to -17.3)
Placebo high dose group:
-17.5 (95%CI -19.8 to -15.2)
Low dose group:
-18.2 (95%CI -19.5 to -17.0)
Placebo low dose group:
-14.9 (95%CI -17.6 to -12.3)
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