Appendix 1: Protocol changes
The changes to the protocol were a result of converting the original systematic review protocol to a scoping review due to the lack of eligible studies found on the original search. The changes included:
Changing the aim of the systematic review from evaluating the efficiency of gabapentinoid deprescribing interventions, to including research questions related to assessing the extent and nature of gabapentinoid deprescribing interventions.
Expanding the population to include adults prescribed gabapentinoids for any indication.
Appendix 2 : Search strategy
Medline, EMBASE, PsycINFO, Cochrane Central Register of Controlled TrialsĀ (CENTRAL) and International Pharmaceutical Abstracts (via Ovid)
((randomised controlled trial or randomized controlled trial or controlled clinical trial or comparative study or clinical trial or pragmatic clinical trial or cross-over stud* or random* or usual care or active control) and (pain or adults) and (pregabalin or lyrica or gabapentin or neurontin or gabapentinoid) and (withdraw* or wean* or detox* or ceas* or cessation or reduc* or taper* or stop* or terminat* or remove* or substitu* or deprescribe or discontinue* or mitigat* or inappropriate or treatment or (therapy or therapies) or interdisciplinary program))