From the word go till nowadays, laboratory biologists have been focused
mostly on a few practical biological models, which largely determined
and narrowed down our modern vision of diverse complex physiological
cellular and molecular bioprocesses. The choice of model organism is an
important issue in experimental biology, particularly, in space
exploration biomedical science. Largely unknown non-classical aquatic
model organisms will be advantageous for further developments on the
path of humanity into space. Selected perspective hydrobiont models
based on old almost-forgotten and new literature data are discussed that
could be of future use in the expanding biomedical space science.