2.9. Analysis of Kd and IC50 value of monoclonal antibodies
against SARS-CoV-2 spike variants
The Kd values of the 74 monoclonal antibodies which are available
publicly in research articles were collected and was tabulated against
the wildtype as well spike variants. Similarly, the IC50values were also tabulated from the available in vitro studies from
different research articles and was compared with that of wild type or
other SARS-CoV-2 spike variants. The variations in the Kd value as well
as IC50 was denoted with red color which denotes the
reduction in binding affinity as well as the efficacy of antibody
neutralization.