2.8. Structural annotation of mAb epitopes in SARS-CoV-2 spike glycoprotein
The Protein Data Bank (PDB) structure of SARS-CoV-2 S-ACE2 complex (7DF4) was used to annotate the epitope residues of SARS-CoV-2 neutralizing mAbs. Independent mAb binding residues tabulated in an excel sheet were used for highlighting the mAb binding residues. All the non-mutated mAb binding residues on SARS-CoV-2 spike were depicted in yellow surface representation. The mAb binding residues that are mutated in the SARS-CoV-2 VOCs were marked in sphere representation in red color while the regions excluding all the epitope residues were colored in grey.