Effects of COX‑2 depletion on the expression of PGs.
In the result of HPLC/mass spectrometry, we found the expression of PGE2 decreased significantly in COX-2KO mice compared with WT ones (Fig. 5A). However, PGD2, PGF2a, 6-Keto-PGF1a and TxB2 these four types of prostaglandins showed no significant difference between WT and COX-2KO group (Fig. 5B-D).