Author contributions
S.C. and K.M.C conceived the study and designed the experiments, with contributions from G.D. Mouse experiments and analyses were done by S.C. with help from G.D., C.W., and Y.D. Vascular function studies were undertaken by S.C., C.W., and D.A.Y. The manuscript was drafted by S.C., K.M.C., and G.D. All authors discussed the results and had the opportunity to contribute to the manuscript.