Acknowledgements
This study was supported by a British Heart Foundation (BHF) Programme Grants (RG/12/5/29576 and RG/17/10/32859), BHF Project Grant (PG/19/48/34433), BHF Chair award (CH/16/1/32013), Oxford BHF Centre of Research Excellence (RE/13/1/30181), and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre.