CONCLUSION
Our study characterizes the mixed phenotype of dilated cardiomyopathies
who have established nonischemic triggers and concomitant moderate CAD,
in a cohort who had received an ICD. The prognosis in patients with
mixed CMP, with regards to device therapies and all-cause mortality,
resembles ICM. The prognosis in patients with mixed CMP is poorer than
NICM in terms of significantly higher burden of comorbidities, poorer LV
functions and trend towards higher proportions of device shocks and
higher mortality. The higher mortality seems to be driven by higher
incidences of non-cardiac deaths thus representing a sicker subset than
NICM. Large-scale studies focusing on this phenotype need to assess the
mediators of poorer prognosis due to underlying pathophysiological
substrate and the associated coexisting illnesses.