Allopurinol maintenance dose prediction
Table 3 presents the predicted allopurinol daily maintenance
dose to achieve serum urate of <6 mg/dL with 75% of success
rate. In general, individuals with lower FFM or higher CrCL require
lower allopurinol dose. Individuals with SLC22A12 rs505802 T
allele or PDZK1 rs1219861 G allele require a higher allopurinol
dose. Individuals with chronic kidney disease (CrCL <60
mL/min) who carry both SLC22A12 rs505802 TT and PDZK1rs1219861 GG genotypes require a higher than maximum dose, and hence
would be candidates for alternative medications.