Parameter
Base model (RSE%)
Final model (RSE%)
Bootstrap, median (95%CI)
Fixed parameters Fixed parameters Fixed parameters Fixed parameters
CL/fm (L/h) 1 (7) 1.05 (10) 1.04 (0.88, 1.31)
V/fm (L) 47.7 (12) 59.3 (9) 59.1 (51.3, 71.9)
Kfm (/h) 1.1 (fixed) 1.1 (fixed) 1.1 (fixed)
BLurate (mg/dL) 9.3 (3) 9.0 (4) 9.0 (8.3, 9.6)
Imax (mg/dL) 6.1 (18) 7.6 (25) 7.3 (4.9, 14.4)
IC50 (mg/L) 8.0 (53) 17.6 (48) 16.5 (6.0, 50.4)
Effects of covariates on CL/fm Effects of covariates on CL/fm Effects of covariates on CL/fm Effects of covariates on CL/fm
Standardized creatinine clearance (power) - 0.45 (31) 0.46 (0.14, 0.77)
SLC22A12 rs505802 T allele - 1.32 (36) 1.32 (1.1, 1.57)
Effects of covariates on baseline SU Effects of covariates on baseline SU Effects of covariates on baseline SU Effects of covariates on baseline SU
Standardized creatinine clearance (power) - -0.18 (66) -0.18 (-0.42, 0.05)
PDZK1 rs1219861 A allele on IC50 - 0.73 (32) 0.73 (0.50, 1.03)
Random effect parameters, CV% (RSE%) [shrinkage] Random effect parameters, CV% (RSE%) [shrinkage] Random effect parameters, CV% (RSE%) [shrinkage] Random effect parameters, CV% (RSE%) [shrinkage]
BSV CL/fm 42.8 (9) [0%] 28.3 (14) [0%] 26.5 (19.5, 34.4)
BSV V/fm 40.7 (22) [25%] 32.4 (21) [30%] 31.5 (16.0, 46.3)
BSV Kfm 27.9 (fixed) 27.9 (fixed) 27.9 (fixed)
BSV BLurate 11.1 (30) [11%] 13.7 (18) [6] 13.3 (8.6, 19.5)
BSV Imax 32.4 (fixed) 32.4 (fixed) 32.4 (fixed)
BSV IC50 71.8 (fixed) 71.8 (fixed) 71.8 (fixed)
Residual error Residual error Residual error Residual error
Serum oxypurinol, proportional (CV%) [shrinkage] 5.2 (33.3) [23.2%] 5.2 (17.9) [21.3%] 5.2 (4.2, 6.1)
Serum urate, additive (mg/dL) [shrinkage] 0.90 (53) [16%] 0.69 (33) [18%] 0.59 (0.25, 1.08)