PCOS-related metabolic alterations exhibit positive associations
between uric acid and fructose
As described previously, both serum fructose and uric acid levels were
strongly associated with PCOS-related metabolic alterations, we used RCS
to detect a possible dependency of serum levels of uric acid and
fructose in PCOS with diverse metabolic
disorders.
Serum uric acid levels were markedly and positively associated with
serum fructose levels in PCOS in all metabolic disorders; however, no
such correlation was observed in the corresponding control participants
(Figure 2). In the obese PCOS subgroup,
there was a non-linear correlation
between serum uric acid and fructose levels in PCOS
(P overall < 0.001,P non-linear = 0. 02; Figure 2b). Additionally,
serum uric acid levels linearly associated with fructose levels in PCOS
with insulin resistance, dyslipidemia and metabolic syndrome (Figure 2d,
f, h).
These results suggested that the correlation between elevated serum uric
acid and fructose levels in PCOS could be attributed to PCOS itself and
was independent of the metabolic disorders in the
population.