Abstract
Objective To investigate
the relationship between serum fructose and uric acid levels in patients
with polycystic ovary syndrome (PCOS).
Design A case-control study.
Setting University-affiliated in vitro fertilization clinic.
Population 292 patients with PCOS and 482 controls.
Main Outcome Measures Serum fructose, uric acid and metabolic
measurements.
Results Compared with controls, serum fructose and uric acid
levels were significantly increased in women with PCOS and patients with
PCOS accompanied by metabolic disorders exhibited higher serum fructose
and uric acid levels (P < 0.001). Restricted cubic
splines indicated that serum uric acid levels linearly and positively
correlated with serum fructose levels in women with PCOS
(P overall < 0.001,P non-linear = 0.30), whereas no correlation was
found in controls (P overall = 0.712,P non-linear = 0.43). Additionally, even after
adjusting for confounding factors, serum fructose levels were an
independent risk factor for hyperuricemia in patients with PCOS
(P = 0.001; odds ratio, 1.380; 95% confidence interval,
1.207–1.577).
Conclusions There was a significantly positive association of
elevated uric acid levels with serum fructose levels in PCOS and was
closely correlated with PCOS-related metabolic disorders, highlighting
the importance of further research into the biological mechanisms of
fructose and uric acid in the development of PCOS.
Funding National Natural Science Foundation of China (No.
82071607 and 32100691); LiaoNing Revitalization Talents Program (No.
XLYC1907071); Fok Ying Tung Education Foundation (No. 151039); Key
Research and Development Program of Liaoning Province (No. 2018225062);
Outstanding Scientific Fund of Shengjing Hospital (No. 202003).
Keywords Fructose; Uric acid; PCOS; Metabolic disorder
Tweetable abstract Elevated serum uric acid levels in PCOS are
positively correlated with serum fructose levels, particularly in PCOS
patients with metabolic disorders. These observations suggest a link
between elevated serum uric acid and fructose metabolic dysfunction in
PCOS and fructose-associated elevation of uric acid may play a key role
in PCOS-related metabolic disorders.