PCOS-related metabolic alterations exhibit positive associations between uric acid and fructose
As described previously, both serum fructose and uric acid levels were strongly associated with PCOS-related metabolic alterations, we used RCS to detect a possible dependency of serum levels of uric acid and fructose in PCOS with diverse metabolic disorders.
Serum uric acid levels were markedly and positively associated with serum fructose levels in PCOS in all metabolic disorders; however, no such correlation was observed in the corresponding control participants (Figure 2). In the obese PCOS subgroup, there was a non-linear correlation between serum uric acid and fructose levels in PCOS (P overall < 0.001,P non-linear = 0. 02; Figure 2b). Additionally, serum uric acid levels linearly associated with fructose levels in PCOS with insulin resistance, dyslipidemia and metabolic syndrome (Figure 2d, f, h).
These results suggested that the correlation between elevated serum uric acid and fructose levels in PCOS could be attributed to PCOS itself and was independent of the metabolic disorders in the population.