Study selection and data extraction
Duplicate records were removed, and records retrieved via electronic
search were then downloaded and imported into a Reference Manager
database and uploaded to InsightScope, a web platform specifically
designed to facilitate systematic reviews (KoH).7Records were appraised against the inclusion criteria using a three-step
method: initial review for inclusion based on defined criteria (MS,
KoH), abstract review (LI, SD) with arbitration (ML, RK, JL), and
full-text review (LI, SD) with arbitration (ML, RK, JL). All included
records subsequently underwent data extraction independently by two
reviewers (LI, SD). Variables of interest included country, study
design, patient population, refractory ITP definition, treatment
regimen, patient outcomes, and laboratory testing.