1 | INTRODUCTION
Rarely seen, Neonatal Lupus erythematosus (NLE) is characterized by
cutaneous lesions and/or congenital heart block in infants at birth or
shortly afterwards. This syndrome is linked to the mother’s
transplantation of maternal auto antibodies (usually anti Ro/SS-A,
La/SS-B or rarely anti-U(1)RNP). Mothers of affected children may have
signs of Sjögren’s Syndrome or other Connective Tissue Diseases, or they
may be asymptomatic.1
In light of decreasing global fertility rates, numerous nations are
implementing measures to encourage higher fertility rates and encourage
more families to have a second child.2 Therefore, it
is estimated that the incidence rate of NLE in siblings will increase
too, so we should raise the awareness of NLE in siblings, which is very
important for the monitoring, evaluation, diagnosis and management of
NLE.
2 | METHODS We collect clinical data of two siblings with NLE, including their
medical history, clinical images, and results from laboratory and
pathological examinations. We aim to compare and analyze the differences
in clinical manifestations between the siblings, as well as track their
prognosis.