Abstract
Neonatal lupus erythematosus (NLE) is a rare disease that is caused by an abnormal immune response. While reported cases of NLE among siblings have demonstrated similar manifestations, we present 2 cases of cutaneous NLE occurring in siblings with significantly different cutaneous manifestations, an uncommon occurrence. The two-child policy led to more families having a second child, so the incidence rate of NLE in siblings may increase too.