Abbreviations: RDV, remdesivir; SD, standard deviation.
Analyzing the effect of initiating RDV therapy with respect to the age
of patients in the groups> 60 and > 80 years,
no differences in the need for oxygen therapy, mechanical ventilation,
or mortality were documented in the two waves between patients who
received the drug within 5 days and those who started treatment more
than 5 days after the onset of symptoms.
A comparison of patients treated with RDV in both waves of the pandemic
showed that, at baseline and subsequent time points, patients infected
with the Delta variant required oxygen supplementation or non-invasive
ventilation more frequently, while patients admitted to the hospital
during the Omicron wave were hospitalized for a shorter period. However,
after hospital discharge, Omicron-infected patients were more likely to
report activity limitations (20.8 vs. 45.6% on day 28) (Figure 2).