Abbreviations: AVT, antiviral therapy; ALT, alanine aminotransferase; ARDS, acute respiratory distress syndrome; CRP, C-reactive protein; IL-6, interleukin-6; PCT, procalcitonin; RDV, remdesivir; SD, standard deviation; SpO₂, saturation of peripheral oxygen; WBC, white blood cells.

Despite the lack of differences in baseline demographic and clinical characteristics in both waves of the pandemic, patients treated with RDV during the Delta predominance period presented significantly lower mean white blood cell, neutrophil, and platelet counts and D-dimer concentrations, while during the Omicron predominance period, lower platelets and IL-6 levels compared to those not receiving antiviral treatment (Table 2).