ABSTRACT
Several vaccines were developed and approved after the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) or COVID 19 pandemic in a relatively short period. However many side effects are still reported and the safety profile of all vaccines remains an area of concern. Complex regional pain syndrome is a rare and uncommon adverse effect to COVID-19 vaccination.
Herein, we describe the case of a patient with complex regional pain syndrome (CRPS) of the right knee that occurred after the second dose of mRNA COVID-19 vaccination.
We discuss this case and tried to clarify the association between CRPS and COVID-19 vaccination which is more likely explained by an immune-mediated inflammatory response to the vaccine component or antigen. Treatment requires a multidisciplinary management, including many medications, physiotherapy and psychological approach. More data were needed on the pathogenesis and the treatment of this unusual complication.
Keywords : COVID-19 vaccine ; complex regional pain syndrome ; reflex sympathetic dystrophy syndrome