Key Results
Geranyl benzoate including four (4) antiviral compounds, D-Limonene,
p-Cymene, Thymol, L-.alpha.- Terpineol and 1,2-Benzenedicarboxylic acid,
butyl -2- methylpropyl ester (1,2BAB-2-MPE) were obtained from fractions
of alcoholic SM leaf extracts and 98% pure Geraniin respectively.In silico analysis identified 1,2BAB-2-MPE as the most favourable
potential binders MARV VP35 binder characterised by high-affinity
interactions binding site residues which favour pocket stability.
Conclusions and
Implications
Our findings, identified Geranyl benzoate compound reported for the
first time in ethanolic leaf extracts of SM and 1,2BAB-2-MPE as
potential anti-filoviral candidate against Marburg viruses VP35. Our
study may provide insights further developed 1,2BAB-2-MPE and /or SM
leaf extracts as a therapeutic agent against Marburg viruses