2.7.1 System preparation
The x-ray crystal structure of the Marburg virus (MARV) VP35 crystal structure was retrieved from the Protein Data Bank (Berman et al., 2002) with code 4GHA (Bale et al., 2012). The retrieved x-ray crystal structure consisted of four chains forming a tetramer and was complexed with the nucleic acid. We deleted all chains, water molecules and nucleic acids except chain A in preparation for molecular docking using UCSF Chimera (Pettersen et al., 2004). Hydrogen atoms were subsequently added and the structure was saved for molecular docking using AutoDock Vina (Trott and Olson, 2010).