Key Results
Geranyl benzoate including four (4) antiviral compounds, D-Limonene, p-Cymene, Thymol, L-.alpha.- Terpineol and 1,2-Benzenedicarboxylic acid, butyl -2- methylpropyl ester (1,2BAB-2-MPE) were obtained from fractions of alcoholic SM leaf extracts and 98% pure Geraniin respectively.In silico analysis identified 1,2BAB-2-MPE as the most favourable potential binders MARV VP35 binder characterised by high-affinity interactions binding site residues which favour pocket stability.
Conclusions and Implications
Our findings, identified Geranyl benzoate compound reported for the first time in ethanolic leaf extracts of SM and 1,2BAB-2-MPE as potential anti-filoviral candidate against Marburg viruses VP35. Our study may provide insights further developed 1,2BAB-2-MPE and /or SM leaf extracts as a therapeutic agent against Marburg viruses