Selection of cohorts from Flatiron Health database
We used the following criteria to select advanced NSCLC Patients and
advanced head and neck patients from Flatiron Health database16. 1) The
patient should be >= 18 years of age at advanced diagnosis.
2) There should be some kind of activity (in drug administration or
visit table) within 90 days of the advanced diagnosis. 3) The patient
should have at least 1 record of systemic anti-cancer drugs 4) Exclude
drug records that are part of clinical trials. This resulted in 4,784
NSCLC patients and 422 advanced head and neck cancer patients included
in this study.The demographic profiles for these patients are described
in Table S1 .