Abstract
Nowadays apparently harmless and commensal Candida species specially, uncommon and rare ones, cause a rising number of infections although, very rare, but if they aren’t treated, they can become serious and result in permanent consequences. Candida species can cause conjunctivitis after trauma and antibiotic therapy to an inflamed eye.Candida metapsilosis is a recently described yeast, phenotypically indistinguishable from Candida parapsilosis , and molecular methods are essential for its detection. We report the first case of Candida conjunctivitis due to Candida metapsilosisobtained from the eye discharge of 40-day-old girl with congenital heart disease admitted in the cardiac intensive care unit (CICU). The yeast isolate was identified by traditional and molecular methods such as PCR-RFLP and sequencing of the entire ITS  genomic region (ITS1, ITS2 and 5.8 rRNA). Antifungal susceptibility test performed according to the CLSI M27-A3, showed that the isolate was susceptible to amphotericin B, Itraconazole, voriconazole, clotrimazole, nystatin, terbinafine, 5-fluorocytosine and caspofungin whereas was resistant to fluconazole, anidulafungin and micafungin.
Keywords: Candida metapsilosis , pediatrics, uncommon Candida, Antifungal susceptibility test