FIG. 5. Longitudinal analysis of wild-type (WT) S and S, N and M protein peptide pool-specific interferon-γ (IFN-γ)+CD4+ and CD8+ T cells by vaccine brand and route. S-specific IFN-γ+CD4+ and CD8+ T cell responses are shown in A and B respectively for both BNT162b2 and CoronaVac recipients, while added SNM-specific IFN-γ+CD4+ and CD8+ T cell responses are shown in C and D for CoronaVac recipients. Samples from the same patient were paired between baseline and post-dose 2 timepoints as well as post-dose 2 and post-dose 3 timepoints, and compared with paired t test after natural logarithmic transformation with p-values denoted ( **, P<0.01; ns, not significant).