5 Conclusion
To conclude, the effect of PPIs on the efficacy of certain anticancer
agents, particularly TKIs, is a major issue in daily practice. In this
opinion paper, although the famitinib has pH-dependent solubility in
vitro, the PPI omeprazole had minimal effect on the PK of famitinib and
SHR116637 in healthy subjects. Therefore, famitinib as a formulated
tablet can be administered with or without ARAs such as PPIs, antacids,
and H2 blockers. In addition, interactions caused by
other factors involved in absorption, apart from the pH effect, need to
be considered during drug development on a case-by-case basis.