5 Conclusion
To conclude, the effect of PPIs on the efficacy of certain anticancer agents, particularly TKIs, is a major issue in daily practice. In this opinion paper, although the famitinib has pH-dependent solubility in vitro, the PPI omeprazole had minimal effect on the PK of famitinib and SHR116637 in healthy subjects. Therefore, famitinib as a formulated tablet can be administered with or without ARAs such as PPIs, antacids, and H2 blockers. In addition, interactions caused by other factors involved in absorption, apart from the pH effect, need to be considered during drug development on a case-by-case basis.