Agent |
Pharmacokinetic parameters(unit) |
Geometric Mean |
Geometric Mean |
Ratios (90%
CI) |
CV (%) |
|
|
Famitinib + Omeprazole |
Famitinib |
|
|
Famitinib |
Cmax (ng/mL) |
42.0 |
42.5 |
0.989(0.953, 1.027) |
6.8 |
|
AUC0-t (h·ng/mL) |
1333.2 |
1395.0 |
0.956(0.907, 1.007) |
9.5 |
|
AUC0-∞ (h·ng/mL) |
1351.9 |
1417.9 |
0.953(0.905, 1.005) |
9.6 |
SHR116637 |
Cmax (ng/mL) |
1.5 |
1.9 |
0.851(0.786, 0.920) |
14.5 |
|
AUC0-t (h·ng/mL) |
96.3 |
108.2 |
0.890(0.838,
0.946) |
11.1 |
|
AUC0-∞ (h·ng/mL) |
105.5 |
118.9 |
0.887(0.835,
0.943) |
11.2 |