Administration mode Pharmacokinetic parameters(unit) Famitinib Famitinib Famitinib SHR116637 SHR116637 SHR116637
Mean ± SD
Geometric Mean (CV%)
Median (minimum-maximum)
Mean ± SD
Geometric Mean (CV%)
Median (minimum-maximum)
Famitinib Tmax* (h) 5.65 ± 0.875 - 6.00 (3.00, 7.00) 5.8 ± 1.64 - 5.00 (5.00, 12.00)
Cmax (ng/mL) 43.2 ± 7.8 42.5 (19.6) 43.8 (25.7, 55.3) 1.9 ± 0.5 1.8 (28.9) 1.9 (1.2, 3.1)
AUC0-t (h·ng/mL) 1425.5 ± 296.3 1395.0 (22.1) 1391.2 (778.0, 2052.3) 115.8 ± 44.6 108.2 (39.4) 108 (46.0, 201.4)
AUC0-∞ (h·ng/mL) 1450.8 ± 312.0 1417.9 (22.7) 1407.1 (787.6, 2125.6) 128.0 ± 52.2 118.9 (41.0) 119.3 (50.8, 233.6)
t1/2 (h) 32.5 ± 5.6 32.1 (17.0) 31.3 (24.6, 45.5) 53.2 ± 9.4 52.4 (17.3) 51.7 (40.0, 76.3)
CL/F (L/h) 18.1 ± 4.4 17.6 (22.7) 17.8 (11.8, 31.7) - - -
Vz/F (L) 837.7 ± 221.2 815.3 (23.3) 794.9 (529.6, 1606.4) - - -
Famitinib + Omeprazole Tmax* (h) 6.7 ± 1.03 6.50 (5.00, 8.00) 6.9 ± 2.07 6.50 (5.0, 12.0)
Cmax (ng/mL) 42.7 ± 7.3 42.0 (18.2) 42.4 (28.0, 57.6) 1.6 ± 0.5 1.5 (33.5) 1.5 (0.9, 2.8)
AUC0-t (h·ng/mL) 1355.0 ± 247.1 1333.2 (18.8) 1312.7 (885.1, 1875.5) 101.7 ± 34.6 96.3 (35.4) 97.1 (53.9, 185.4)
AUC0-∞ (h·ng/mL) 1375.1 ± 257.0 1351.9 (19.3) 1321.8 (895.1, 1915.0) 111.7 ± 38.8 105.5 (36.1) 106.9 (58.1, 203.3)
t1/2 (h) 32.0 ± 4.7 31.7 (14.0) 30.7 (26.3, 44.5) 52.8 ± 9.2 52.2 (16.3) 51.6 (40.1, 81.5)
CL/F (L/h) 18.8 ± 3.7 18.5 (19.3) 18.9 (13.1, 27.9) - - -
Vz/F (L) 859.7 ± 161.7 846.0 (18.4) 825.6 (618.8, 1272.6) - - -