Figure legends
Figure 1 . Graphical overview of the MR study design. The Mendelian Randomization (MR) design indicates that the genetic variants proposed as instrumental variables (IVs) should be robustly associated with the risk factor of interest; the selected IVs should not be associated with potential confounders and affect the risk of the outcome merely through the risk factors, not via alternative pathways. The genetic variants, selected as IVs for studying the effect of modifying the exposure, are randomly allocated at conception and are therefore less vulnerable to confounding from environmental factors and reverse causation. Multiple analyses are conducted to assess the causal relationship between lifestyle factors and the risk of ovarian cancer subtypes.
Figure 2 . Associations of genetically predicted lifestyle factors and ovarian cancer subtypes. The OR (95% CI) of ovarian cancer subtypes were estimated using an inverse-variance weighted meta-analysis.