Study |
Year |
number |
Gestation age(weeks) |
Gestation age(weeks) |
intervention |
Outcomes |
|
|
|
caffeine |
theophylline |
|
|
Iranpour |
2022 |
45/45 |
31.37 (1.55) |
31.50 (1.50) |
The initial
loading dose of 10 mg/kg and a daily dose of 10 mg/kg of caffeine was
used after birth, as the daily maintenance dose until the infants
tolerated without respiratory support with NCPAP or free oxygen
administration |
①⑤⑥⑦⑧ |
Elmowafi |
2021 |
90/91 |
28.6 ± 2.1 |
28.8 ± 1.8 |
Received intravenous
caffeine citrate within the first 72 h of life before the existence of
AOP or the need for MV. Caffeine citrate was given as a loading dose of
20 mg/kg/day and a maintenance dose of 10 mg/kg/day. |
①②③④⑤⑥⑦⑧⑨ |
Chen K
|
2020
|
26/30
|
30.44±1.09
|
29.91±1.29
|
intravenous infusion of 20 mg/kg caffeine citrate each time within 8-12
hours after birth, Intravenous infusion at a dose of 5 mg/kg per day was
given after 24
hours; the maintenance dose was increased to 10 mg/kg in the presence of
persistent AOP
|
②④
|
Fakoor |
2019 |
50/50 |
29.04 ± 1.30 |
29.38 ± 1.0 |
20 mg/kg of venous
caffeine was injected to Group A in the 2nd day of birth (24-48
h),Then, a maintenance dose was injected 24 h after the first injection
with the daily dose of 5 mg/kg. |
⑤⑧⑨ |
Ke H |
2018 |
539/557 |
29.7±4.5 |
30.1±3.9 |
Give caffeine citrate
immediately after admission, the first dose was 20mg/kg intravenously
for 30min, and the maintenance dose was 10mg/(kg·d) 24h late |
②③④⑥⑦ |
Amaro |
2018 |
41/42 |
25.7 (24.3-27.0) |
26.1 (24.2-28.4) |
a loading
dose of caffeine citrate 20 mg/kg from 24h after birth followed by a
maintenance dose of 5 mg/kg/day. |
②③④⑨ |
Zhao Y |
2017 |
66/66 |
29.15±1.67 |
29.67±1.65 |
intravenously for
30min from 24h after birth, the first dose was 20mg/kg, and maintained
at 5mg/kg 24h later, every 24H1, until the gestational age reached 34
weeks |
①④⑤⑦ |
Zhao Z |
2017 |
65/61 |
31.4±2.7 |
31.9±2.5 |
Caffeine citrate was
administered immediately after birth (all doses were administered within
2h after birth). The first load dose was 20mg/kg, pumped intravenously
at 30min, and the maintenance dose was 5mg/kg intravenously at 24h |
①②③④⑥⑦⑧⑨ |
Armanian |
2016 |
26/26 |
28.7±1.95 |
28.57±2.06 |
caffeine 20 mg/kg
(intravenously (IV)) was administered as the initial dose on the 1st day
of life, and then 5 mg/kg (intravenously) daily was used as the
maintenance dose for the first 10 days of life |
①④⑦⑧⑨ |
Davis |
2010 |
233/220 |
27.3(1.84) |
27.8(1.76) |
A loading dose of 20
mg of caffeine citrate per kilogram of body weight from 24h after birth
was followed by a daily maintenance dose of 5 mg/kg |
②⑤⑨ |
Schmidt |
2006 |
1006/1000 |
27±2 |
27±2 |
loading dose of either 20 mg
of caffeine citrate per kilogram of body weight from 24h after birth and
followed by a daily maintenance dose of 5 mg per kilogram |
④⑤⑥ |