Bronchopulmonary dysplasia
The number of newborns with BPD in the prophylactic caffeine group and
control group was observed in 8 trials (4113 infants). We indicated that
the occurrence of BPD was lower in the caffeine group than that in the
control group (OR 0.62, 95%CI: 0.54-0.71, P< 0.001).
There was no significant heterogeneity between these research
(I2 =0.0%, P = 0.639, Figure 4A).