CoALL08- 09 high- risk- intensified:
Treatment backbone was identical except for the following differences:
- use of pegylated asparaginase (2500 IE/m2) within
block 1a, 1b and 3a.
- C3b: clofarabine (5x 40 mg/m²), pegylated asparaginase (2500
IE/m2), methotrexate intrathecal (age-dependent
dose)
- AEP: amsacrine (2 x 100 mg/m2), etoposide (2 x 500
mg/m2) and methylprednisolone (4 x 1000
mg/m2)