Assessment of AEP toxicity
Detailed toxicity data on AEP treatment were available from 94 patients
(72/77 HR-I and from all 22 IF patients). Beside myelosuppression,
infections accounted for the largest fraction among documented adverse
complications (table 3). In the pooled analysis there were two reports
of SAE caused by septicemia with Escherichia coli in the HR-I group and
a perianal abscess formation among induction failure patients. Yet, no
AEP-related death occurred. In thirty-four patients no toxicity was
reported after AEP except an anticipated myelosuppression. The median
time interval between the start of the AEP block and the subsequent CNS
phase in late consolidation was 33 days (range: 19 to 69 days) which is
comparable to other intensive chemotherapy courses .