Figure 1 Infographic illustrating how the experimental cohorts contributed to the different populations.

Figure 2: Mean arterial pressure (MAP) versus time; comparison between male (blue circles) and female (red squares) in Lewis rats. The difference was significant * at 120 minutes. Data presented as mean ± SD; later time points are presented as single recorded points as they were measured at different times.

Figure 3: Alphaxalone plasma concentration-time curves; comparison between observed/simulated male (blue squares/lines) and female (red circles/lines) in Lewis rats for the same dosing regimen: 1.67 mg kg^-1minute^-1 for 2.5 minutes followed by 0.75 mg kg^-1minute^-1until the end of the electrophysiological stage, then by 0.52 mg kg^-1minute^-1

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