Figure 1 Infographic illustrating how the experimental cohorts
contributed to the different populations.
Figure 2: Mean arterial pressure (MAP) versus time; comparison between
male (blue circles) and female (red squares) in Lewis rats. The
difference was significant * at 120 minutes. Data presented as mean ±
SD; later time points are presented as single recorded points as they
were measured at different times.
Figure 3: Alphaxalone plasma concentration-time curves; comparison
between observed/simulated male (blue squares/lines) and female (red
circles/lines) in Lewis rats for the same dosing regimen: 1.67 mg
kg-1minute-1 for 2.5 minutes
followed by 0.75 mg kg-1minute-1until the end of the electrophysiological stage, then by 0.52 mg
kg-1minute-1
A B