Double pollen-sensitization
Tree pollen: In 131 patients birch extract, ash-tree-extract, Bet v 1 and Ole e 1 IgE were determined. 117 patients showed a positive result to ash-tree extract, and 104 to birch. Twenty patients were mono-sensitized to ash-tree extract, while 7 were mono-sensitized to birch. Seven of 131 were negative for both birch and ash-tree extract. The 97 patients who were positive for birch and ash-tree extract (=double-sensitized) were further evaluated using the major allergens (Figure 2A). While 74/97 patients had a double-sensitization to Bet v 1 and Ole e 1, 15 were positive only for Bet v 1, 4 only for Ole e 1, and 4 were negative for Bet v 1 and Ole e 1.
Weeds-Pollen: We obtained results for mugwort extract, ragweed extract and the major allergens Art v 1 and Amb a 1 in 158 patients. Looking at the extracts, 137 were positive for ragweed and 121 for mugwort. Six were mono-sensitized to mugwort, 22 to ragweed. Further evaluation was done for 115 patients with double-sensitization to both extracts (Figure 2B). Twenty-nine of 115 patients were double-sensitized to both major allergens Art v 1 and Amb a 1. Seventeen patients were exclusively positive to Art v 1, whereas 48 patients were exclusively positive to Amb a 1. 21 patients were double-negative for Art v 1 and Amb a 1.