Time intervals presented in units of hours from presentation. HR = heart rate (beats/minute); Fset=mandatory respiratory rate (breaths/minute); Ftot = total respiratory rate (breaths/minute); Vt = tidal volume; PS = pressure support applied to spontaneous breaths; PEEP = positive end-expiratory pressure; PIP = peak inspiratory pressure; C = static compliance; Cwt = static compliance indexed for body weight in kilograms; I:E ratio = inspiratory to expiratory ratio; FiO2 = fractional inspired oxygen concentration; SpO2 = pulse oximetry; ETCO2 = end-tidal carbon dioxide; PvCO2 = venous carbon dioxide tension; PaCO2 = arterial carbon dioxide tension; PaO2 = arterial oxygen tension; P:F ratio = PaO2:FiO2 ratio. * = prior to adopting ARDSnet settings; ** = immediately prior to extubation.
Table 4 - Positive end-expiratory pressure and fractional inspired oxygen settings used, adapted from the ARDSnet trial.10