Figure2. Safety and adaptability evaluation of allicin topical application on guinea pig and rabbit skin. Edema (A) and erythema (B) scores were recorded at 6h, 24h, 48h, and 72h during the stimulation phase of the anaphylaxis test (n=12). (C) Cumulative scores of skin irritation after allicin topical application with different concentrations in rabbits for 4 months. Effects on body weight (D) and major organ index (E) of different concentrations of allicin applied to rabbit skin for 4 months. (F) Hematologic studies before 3 days and after 92 days of allicin topical administration (n=6). Data are expressed as means ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.