Measurement of Skin Inflammation Severity
We used the cumulative Psoriasis Area and Severity Index (PASI) score to assess the severity of skin lesions, which consists of erythema, scale, and thickness. The score was graded independently from 0 to 4: 0, none; 1, slight; 2, moderate; 3, marked; 4, very marked. The PASI scores of the mice were recorded on the first day of IMQ treatment.