Immune response
As a remote protein, Cas9 may actuate the safe reaction. In spite of the fact that there are not numerous reports approximately the extreme safe response caused by Cas9, the antibodies of Cas9 have been broadly recognized in human bodies [140], which recommends the potential hazard of aggravation amid CRISPR/Cas9-based quality treatment. At show, analysts pay more consideration to the immunogenicity caused by conveyance vectors, particularly the viral vectors, since the human body may have been tainted by these infections some time recently and contain the comparing antibodies as of now. Collectively, the safe response possibly actuated by CRISPR/Cas9 gene-editing framework is one of the major hazard components within the improvement of CRISPR-based quality treatment in vivo.