Figure Legends
Figure 1: Asthma prevalence and ICU admission for hospitalized
COVID-19 patients. (a) Prevalence of asthma in hospitalized COVID-19
patients. The y-axis denotes the prevalence of the precondition asthma
in hospitalized COVID-19 patients in percent. The filled bars correspond
the prevalences of the precondition asthma in hospitalized COVID-19
patients in Germany (Frankfurt, Gießen and Marburg; yellow), Moscow
(orange), and Stanford (purple). The open bars indicate the prevalence
of asthma in the general population in the corresponding areas.
The vertical lines
indicate the 95% Clopper-Pearson confidence interval.
(b) Odds ratios for asthma and ICU admission. The x-axis denotes the
odds ratio between Odds (ICU|asthma) and Odds (ICU|no
asthma). Dots indicate the value of the point-estimate for Germany
(Frankfurt, Gießen and Marburg; yellow), Moscow (orange), and Stanford
(purple). The horizontal lines indicate the 95% confidence interval.
The dotted vertical line denotes an odds ratio of 1, i.e., no
association.
Figure 2: Additional preconditions for hospitalized
COVID-19 patients with or without asthma. (a) Prevalences of additional
preconditions in patients with and without asthma. The y-axes denote the
prevalences of the respective precondition. The filled bars correspond
the prevalences of the respective precondition among hospitalized
COVID-19 patients with asthma in Germany (Frankfurt, Gießen and Marburg;
yellow), Moscow (orange), and Stanford (purple). The striped bars denote
the prevalences of the respective precondition among hospitalized
COVID-19 patients without asthma. The horizontal line indicates
significant differences in the prevalences of the respective
precondition between patients with asthma and without asthma. COPD:
Chronic Obstructive Pulmonary Disease. (b) Frequency of patients with 0
to 11 additional preconditions (except asthma). The x-axis denotes the
number of additional preconditions per patient. The y-axis denotes the
frequency of patients in percent.
Figure 3: Confounder analysis. Odds of being asthmatic
given that the patient was from Stanford is shown on the left (no
adjustment) for the indicated age groups. The odds of being asthmatic
given that the patient was from Stanford, female and had no comorbidity
is shown on the right (adjusted) for the indicated age groups. The
vertical lines indicate the 95% confidence interval. The red horizontal
line indicates the Odds of asthma in the general population.
Figure 4: Peripheral blood eosinopenia for hospitalized
COVID-19 patients with or without asthma . Average eosinophil counts at
admission (Ad), during the hospital stay (Du), and at discharge (Di) for
patients with asthma (solid bars) and without asthma (striped bars). The
y-axis denotes the eosinophil count time s103 per μl. The vertical lines
denote the 95% confidence interval. The numbers below the bars indicate
the number of patients.
Supplementary Figure 2: Laboratory parameters for
hospitalized COVID-19 patients with or without asthma. Average
laboratory parameters at admission (Ad), during the hospital stay (Du),
and at discharge (Di) for patients with asthma (solid bars) and without
asthma (striped bars). The y-axis denotes the value with the indicated
unit. The vertical lines denote the 95% confidence interval. The
numbers below the bars indicate the number of patients.