REFERENCES

1. Steliarova-Foucher E, Colombet M, Ries LAG, et al. International incidence of childhood cancer, 2001–10: a population-based registry study. Lancet Oncol . 2017;18(6):719-731. doi:10.1016/S1470-2045(17)30186-9
2. Pui CH, Yang JJ, Hunger SP, et al. Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration. J Clin Oncol Off J Am Soc Clin Oncol . 2015;33(27):2938-2948. doi:10.1200/JCO.2014.59.1636
3. Murphy RG, Greenberg ML. Osteonecrosis in pediatric patients with acute lymphoblastic leukemia. Cancer . 1990;65(8):1717-1721. doi:10.1002/1097-0142(19900415)65:8<1717::aid-cncr2820650809>3.0.co;2-b
4. Socié G, Sélimi F, Sedel L, et al. Avascular necrosis of bone after allogeneic bone marrow transplantation: clinical findings, incidence and risk factors. Br J Haematol . 1994;86(3):624-628. doi:https://doi.org/10.1111/j.1365-2141.1994.tb04795.x
5. Hines JT, Jo WL, Cui Q, et al. Osteonecrosis of the Femoral Head: an Updated Review of ARCO on Pathogenesis, Staging and Treatment. J Korean Med Sci . 2021;36(24):e177. doi:10.3346/jkms.2021.36.e177
6. Weinstein RS, Nicholas RW, Manolagas SC. Apoptosis of Osteocytes in Glucocorticoid-Induced Osteonecrosis of the Hip1. J Clin Endocrinol Metab . 2000;85(8):2907-2912. doi:10.1210/jcem.85.8.6714
7. Miyanishi K, Yamamoto T, Irisa T, et al. Bone marrow fat cell enlargement and a rise in intraosseous pressure in steroid-treated rabbits with osteonecrosis. Bone . 2002;30(1):185-190. doi:10.1016/s8756-3282(01)00663-9
8. Mattano LA, Sather HN, Trigg ME, Nachman JB. Osteonecrosis as a complication of treating acute lymphoblastic leukemia in children: a report from the Children’s Cancer Group. J Clin Oncol Off J Am Soc Clin Oncol . 2000;18(18):3262-3272. doi:10.1200/JCO.2000.18.18.3262
9. te Winkel ML, Pieters R, Wind EJD, Bessems JHJM, van den Heuvel-Eibrink MM. Management and treatment of osteonecrosis in children and adolescents with acute lymphoblastic leukemia. Haematologica . 2014;99(3):430-436. doi:10.3324/haematol.2013.095562
10. van den Heuvel-Eibrink MM, Pieters R. Steroids and risk of osteonecrosis in ALL: take a break. Lancet Oncol . 2012;13(9):855-857. doi:10.1016/S1470-2045(12)70315-7
11. Mattano LA, Devidas M, Nachman JB, et al. Alternate-Week versus Continuous Dexamethasone Scheduling on the Risk of Osteonecrosis in Acute Lymphoblastic Leukemia: Results from the CCG-1961 Randomized Cohort Trial. Lancet Oncol . 2012;13(9):906-915. doi:10.1016/S1470-2045(12)70274-7
12. Girard P, Auquier P, Barlogis V, et al. Symptomatic osteonecrosis in childhood leukemia survivors: prevalence, risk factors and impact on quality of life in adulthood. Haematologica . 2013;98(7):1089-1097. doi:10.3324/haematol.2012.081265
13. te Winkel ML, Pieters R, Hop WCJ, et al. Prospective Study on Incidence, Risk Factors, and Long-Term Outcome of Osteonecrosis in Pediatric Acute Lymphoblastic Leukemia. J Clin Oncol . 2011;29(31):4143-4150. doi:10.1200/JCO.2011.37.3217
14. Mogensen SS, Harila-Saari A, Mäkitie O, et al. Comparing osteonecrosis clinical phenotype, timing, and risk factors in children and young adults treated for acute lymphoblastic leukemia. Pediatr Blood Cancer . 2018;65(10):e27300. doi:10.1002/pbc.27300
15. Niinimäki T, Niinimäki J, Halonen J, Hänninen P, Harila-Saari A, Niinimäki R. The classification of osteonecrosis in patients with cancer: validation of a new radiological classification system. Clin Radiol. déc 2015;70(12):1439‑44.
16. Niinimäki T, Harila-Saari A, Niinimäki R. The diagnosis and classification of osteonecrosis in patients with childhood leukemia. Pediatr Blood Cancer. 2015;62(2):198‑203.
17. Schmiegelow K, Attarbaschi A, Barzilai S, et al. Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus. Lancet Oncol . 2016;17(6):e231-e239. doi:10.1016/S1470-2045(16)30035-3
18. Berbis J, Michel G, Baruchel A, et al. Cohort Profile: the French childhood cancer survivor study for leukaemia (LEA Cohort). Int J Epidemiol . 2015;44(1):49-57. doi:10.1093/ije/dyu031
19. Jaramillo D. What is the optimal imaging of osteonecrosis, Perthes, and bone infarcts? Pediatr Radiol . 2009;39 Suppl 2:S216-219. doi:10.1007/s00247-009-1151-7
20. Saini A, Saifuddin A. MRI of osteonecrosis. Clin Radiol . 2004;59(12):1079-1093. doi:10.1016/j.crad.2004.04.014
21. Sapin C, Simeoni MC, El Khammar M, Antoniotti S, Auquier P. Reliability and validity of the VSP-A, a health-related quality of life instrument for ill and healthy adolescents. J Adolesc Health Off Publ Soc Adolesc Med . 2005;36(4):327-336. doi:10.1016/j.jadohealth.2004.01.016
22. Simeoni MC, Auquier P, Antoniotti S, Sapin C, San Marco JL. Validation of a French health-related quality of life instrument for adolescents: the VSP-A. Qual Life Res Int J Qual Life Asp Treat Care Rehabil . 2000;9(4):393-403. doi:10.1023/a:1008957104322
23. Simeoni MC, Sapin C, Antoniotti S, Auquier P. Health-related quality of life reported by French adolescents: a predictive approach of health status? J Adolesc Health Off Publ Soc Adolesc Med . 2001;28(4):288-294. doi:10.1016/s1054-139x(00)00198-1
24. Leplege A, Ecosse E, Pouchot J. Le Questionnaire MOS SF-36: Manuel de l’utilisateur et Guide d’interprétation Des Scores . ESTEM ed.; 2001.
25. Reulen RC, Zeegers MP, Jenkinson C, et al. The use of the SF-36 questionnaire in adult survivors of childhood cancer: evaluation of data quality, score reliability, and scaling assumptions. Health Qual Life Outcomes . 2006;4:77. doi:10.1186/1477-7525-4-77
26. Landis JR, Koch GG. The Measurement of Observer Agreement for Categorical Data. Biometrics . 1977;33(1):159-174. doi:10.2307/2529310
27. Kunstreich M, Kummer S, Laws HJ, Borkhardt A, Kuhlen M. Osteonecrosis in children with acute lymphoblastic leukemia.Haematologica . 2016;101(11):1295-1305. doi:10.3324/haematol.2016.147595
28. Barzilai-Birenboim S, Yacobovich J, Zalcberg Y, et al. Bone pain at leukemia diagnosis and other risk factors for symptomatic osteonecrosis in children with acute lymphoblastic leukemia. Pediatr Blood Cancer . Published online March 31, 2021:e29033. doi:10.1002/pbc.29033
29. Hernigou P, Bachir D, Galacteros F. The Natural History of Symptomatic Osteonecrosis in Adults with Sickle-Cell Disease.JBJS . 2003;85(3):500-504.
30. Kuhlen M, Kunstreich M, Gökbuget N. Osteonecrosis in Adults With Acute Lymphoblastic Leukemia: An Unmet Clinical Need. HemaSphere . 2021;5(4):e544. doi:10.1097/HS9.0000000000000544
31. Krez A, Lane J, Heilbronner A, et al. Risk factors for multi-joint disease in patients with glucocorticoid-induced osteonecrosis.Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA . Published online April 20, 2021. doi:10.1007/s00198-021-05947-x
32. Kuhlen M, Kunstreich M, Krull K, Meisel R, Borkhardt A. Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge. Blood Adv . 2017;1(14):981-994. doi:10.1182/bloodadvances.2017007286
33. Inaba H, Varechtchouk O, Neel MD, et al. Whole-joint magnetic resonance imaging to assess osteonecrosis in pediatric patients with acute lymphoblastic lymphoma. Pediatr Blood Cancer . 2020;67(8):e28336. doi:10.1002/pbc.28336
34. Karol SE, Mattano LA, Yang W, et al. Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia. Blood . 2016;127(5):558-564. doi:10.1182/blood-2015-10-673848
35. den Hoed MAH, Pluijm SMF, Uitterlinden AG, Pieters R, van den Heuvel-Eibrink MM. Genetic Biomarkers to Identify the Risk of Osteonecrosis in Children with Acute Lymphoblastic Leukemia. Mol Diagn Ther . 2016;20(6):519-522. doi:10.1007/s40291-016-0226-z