Statistical analysis
Statistical analysis was performed by IBM SPSS Statistics 26. CIN1+,
CIN2+ and CIN3+ were used as the observation endpoints, respectively.
The sensitivity, specificity, negative predictive values (NPV), positive
predictive values (PPV) and area under curve (AUC) were calculated to
validate the efficacy of TS either alone or in combination with HPV
test. McNemar’s exact test was used to compare these indicators between
TS, hrHPV and TS combined with hrHPV. Chi-square test and Fisher exact
test was used to evaluate the differences between different groups
regarding TZ type and menstruation status. Spearman correlation analysis
was used to verify the association between TS and p16, Ki-67. For all
the statistical tests, two-sided p-value less than 0.05 was considered
statistically significant.