Table 4. Univariate analysis of factors associated with dose-limiting
toxicities.
We tested the threshold value of 50 mg/L proposed for DLT onset in RCC
patients, but it was not statistically significant (data not shown).
However, a higher average of PAZ Cmin over the first 3 months of
treatment was associated with a higher risk of grades 3-4 toxicities
(40.0 vs 30.5 mg/L (OR 1.05, IC95 [1.01-1.09], p=0.01) (figure 3).