2.1 Study Description
Three clinical studies were pooled together for popPK analysis, including CC-220-CP-001(single ascending dose study in healthy subjects; herein as CP-001; NCT01733875), CC-220-CP-002 (multiple ascending dose study in healthy subjects; herein as CP-002; NCT02034773) and CC-220-MM-001 studies (subjects with RRMM; NCT02773030). Study description was presented in Table 1.
The studies were conducted in accordance with the ethical principles of Good Clinical Practice. All subjects gave written informed consent prior to enrollment. The studies were approved by the institutional review boards of the participating center and were conducted according to the Declaration of Helsinki and the ICH Guidelines for Good Clinical Practice.