3.4 Model Evaluation
The model was validated by visual predictive check (VPC). The results of the VPC evaluation were presented in Figure 6. The 5th, 50th and 95th percentiles of the observed concentration data at each time point were generally contained within the respective 90% CI (shaded area, pink for the 50th percentile and blue for 5th and 95th percentiles) of the simulated data (Figure 5). There was a good agreement in the time course and central tendency between distributions of observed and simulated data, with no obvious bias. Overall, the estimated IIV adequately described the observed variability in iberdomide and M12 concentrations.
Taken together, iberdomide and M12 concentrations were well characterized by the final popPK model. This enabled the proper use of the model for subsequent simulations.