Conclusion
In conclusion, the parent-metabolite population pharmacokinetic model
adequately described the time course PK data of iberdomide and M12.
Iberdomide and M12 show robust PK exposure, not complicated by
demographic factors, combination, hepatic or (mild and moderate) renal
impairments. The model can be used to guide the dosing strategy for
special patient population and inform future iberdomide study design.