2.7 Model Performance
Model evaluation was performed using visual predictive check (VPC) that provided an evaluation of model assumptions and population parameter estimates by comparing model predictions with observations. The ability of the final popPK model to describe the observed concentration data was evaluated by simulating 500 datasets having the same doses, dosing schedules and sampling times as the original dataset and by performing VPCs. Binning of observations around logical post dose time points of interest was done to ensure sufficient density of observations.