UNPREDICTABLE SOUND STRESS MODEL CAUSES MIGRAINE-LIKE BEHAVIORS
IN MICE WITH SEXUAL DIMORPHISM
Fernanda Tibolla Vieroa, Patrícia
Rodriguesa, Julia Maria Frarea,
Náthaly Andrighetto Ruviaro da Silvaa, Marcella de
Amorim Ferreirab, Ana Merian da
Silvab, Gabriele Cheiran Pereiraa,
Juliano Ferreirab, Micheli Mainardi
Pillata, Guilherme Vargas Bocchia,
Romina Nassinic, Pierangelo
Geppettic, Gabriela Trevisana,*
a Graduate Program in Pharmacology, Federal University
of Santa Maria (UFSM), 97105-900 Santa Maria (RS), Brazil.
b Graduate Program in Pharmacology, Federal University
of Santa Catarina (UFSC), 8804-0900, Florianópolis (SC), Brazil.
c Department of Health Science, Clinical Pharmacology
and Oncology, University of Florence (UNIFI), 50139 Florence (TO),
Italy.
*Corresponding author: Gabriela Trevisan, Graduate Program in
Pharmacology, Federal University of Santa Maria (UFSM), Avenida Roraima,
1000, building 21, room 5207, Zip code: 97105-900 Santa Maria (RS),
Brazil, Phone: +55 55 32208976, Email: gabrielatrevisansantos@gmail.com.
Acknowledgments. Prof. Jon D. Levine for helping with
unpredictable sound protocol.
Marylou Ingram Scholarship from International Society for Advancement of
Cytometry (ISAC).
Funding. Fellowships from the Conselho Nacional de
Desenvolvimento Científico (CNPq) and Coordenação de Aperfeiçoamento de
Pessoal de Nível Superior (CAPES) are also acknowledged. Ph.D.
fellowship to F.T.V from CAPES [process #88887.501615/2020-00 and P.R
from CAPES [process #88887.501568/2020-00]. G.T is recipient of a
fellowship from CNPq [process #303531/2020-7].
Conflict of interest. The authors declare that no competing
interests exist.
Declaration of transparency and scientific rigour. This
Declaration acknowledges that this paper adheres to the principles for
transparent reporting and scientific rigour of preclinical research as
stated in the BJP guidelines for Design and Analysis andAnimal Experimentation .
Author’s contributions. FTV and GT: designed the research
(research plan formulation, and study oversight); FTV, PR, JF, NA, MF,
AS, GP, MP, GB, RN, PG and JF performed experiments, analyzed and
interpreted data. FTV and GT interpreted data and contributed to the
writing of the manuscript. All authors read and approved the final
manuscript.
Data availability. The data that support the findings of this
study are available from the senior author
(gabrielatrevisansantos@gmail.com) upon reasonable request.