Background and purpose
Migraine represents one of the major causes of disability worldwide and
is more prevalent in women, it is also related to anxiety symptoms.
Stress is a frequently reported trigger in migraine patients, such as
sound stress, but the underlying mechanisms are not fully understood.
However, it is known that patients with migraine have higher levels of
plasma inflammatory cytokines and calcitonin gene-related peptide
(CGRP). Stress mediated by unpredictable sound is already used as a
model of painful sensitization, but migraine-like behaviors and sexual
dimorphism have not yet been evaluated. This study characterized the
nociception and anxiety-related symptoms after the induction of
unpredictable sound stress in mice.