Key results
These nociceptive and behavioral alterations detected in this model were
shown mostly in female stressed mice. Besides, 7th-day post-stress
nociception, these behaviors were consistently abolished by CGRP
receptor antagonist olcegepant (BIBN4096BS, 100mg/kg by intraperitoneal
route) until 3 h after treatment in stressed mice. In addition, we
demonstrated an increase in levels of IL-6 and TNF-α and CGRP levels in
stressed mice plasma, with female with higher levels when compared to
male mice.