UNPREDICTABLE SOUND STRESS MODEL CAUSES MIGRAINE-LIKE BEHAVIORS IN MICE WITH SEXUAL DIMORPHISM
Fernanda Tibolla Vieroa, Patrícia Rodriguesa, Julia Maria Frarea, Náthaly Andrighetto Ruviaro da Silvaa, Marcella de Amorim Ferreirab, Ana Merian da Silvab, Gabriele Cheiran Pereiraa, Juliano Ferreirab, Micheli Mainardi Pillata, Guilherme Vargas Bocchia, Romina Nassinic, Pierangelo Geppettic, Gabriela Trevisana,*
a Graduate Program in Pharmacology, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria (RS), Brazil.
b Graduate Program in Pharmacology, Federal University of Santa Catarina (UFSC), 8804-0900, Florianópolis (SC), Brazil.
c Department of Health Science, Clinical Pharmacology and Oncology, University of Florence (UNIFI), 50139 Florence (TO), Italy.
*Corresponding author: Gabriela Trevisan, Graduate Program in Pharmacology, Federal University of Santa Maria (UFSM), Avenida Roraima, 1000, building 21, room 5207, Zip code: 97105-900 Santa Maria (RS), Brazil, Phone: +55 55 32208976, Email: gabrielatrevisansantos@gmail.com.
Acknowledgments. Prof. Jon D. Levine for helping with unpredictable sound protocol.
Marylou Ingram Scholarship from International Society for Advancement of Cytometry (ISAC).
Funding. Fellowships from the Conselho Nacional de Desenvolvimento Científico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) are also acknowledged. Ph.D. fellowship to F.T.V from CAPES [process #88887.501615/2020-00 and P.R from CAPES [process #88887.501568/2020-00]. G.T is recipient of a fellowship from CNPq [process #303531/2020-7].
Conflict of interest. The authors declare that no competing interests exist.
Declaration of transparency and scientific rigour. This Declaration acknowledges that this paper adheres to the principles for transparent reporting and scientific rigour of preclinical research as stated in the BJP guidelines for Design and Analysis andAnimal Experimentation .
Author’s contributions. FTV and GT: designed the research (research plan formulation, and study oversight); FTV, PR, JF, NA, MF, AS, GP, MP, GB, RN, PG and JF performed experiments, analyzed and interpreted data. FTV and GT interpreted data and contributed to the writing of the manuscript. All authors read and approved the final manuscript.
Data availability. The data that support the findings of this study are available from the senior author (gabrielatrevisansantos@gmail.com) upon reasonable request.