What this study adds:
● unpredictable sound stress model in mice in addition to causing periorbital/hind paw mechanical allodynia, lead anxiety-like symptoms.
● female mice after stress induction presented higher levels of nociceptive parameters and anxiety-like symptoms
● plasmatic levels of inflammatory cytokines (IL-6 and TNF-α) and CGRP were increased in ST mice, particularly in female ST mice.