CGRP antagonist revert the anxiety-like symptoms and increased
exploratory activity after unpredictable sound stress
The effect of BIBN4096BS treatment in the open field test was evaluating
1 hour after drug administration. Thus, we perceived that this drug was
able to reversion of alterations observed by stress exposition. In
reference to grooming, the treatment reverted this behavior parameter
compared to the vehicle-treated group in males and females ST mice (Fig.
6A). In the same, the treatment reverted the less exploratory behavior
expressed as the time of sniffing in ST vehicle-treated group (Fig. 6B).
Also, BIBN4096BS was able to increase the rearing (Fig. 6C) compared the
stress/vehicle group (Fig. 6D). Regarding the number of crossings, the
treatment reverted the stress affect in female (Fig. 6D and 6E) when
compared to the female of vehicle group. Finally, the treatment reduced
the time spent in the peripheral zone in the ST group when compared to
the vehicle group (Fig. 6F and 6G). The treatment did not affect the
distance traveled (not shown). Therefore, the treatment did not have a
significant difference in their action in male or female ST mice.