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\begin{document}

\title{Assessing long-term renal outcome after allogeneic hematopoietic stem
cell transplantation in children with estimated glomerular filtration
rate equations, based on creatinine and cystatin C levels.}



\author[1]{Aysha Gadashova }%
\author[2]{Seçil Conkar Tunçay}%
\author[3]{Gülcihan Ozek}%
\author[1]{Gülden Hakverdi}%
\author[1]{Savaş Kansoy}%
\author[1]{Caner Kabasakal}%
\author[3]{Serap Aksoylar }%
\affil[1]{Ege University Faculty of Medicine}%
\affil[2]{Ege Universitesi Tip Fakultesi}%
\affil[3]{Ege University}%


\vspace{-1em}



  
  \date{May 24, 2024}


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\selectlanguage{english}
\begin{abstract}
Background: With the widespread use of hematopoietic stem cell
transplantation (HSCT), long-term complications have come to the fore.
The aim of this study is to determine the prevalence and risk factors of
chronic kidney disease (CKD) developing in the long term in patients who
underwent allogeneic HSCT in childhood and also to investigate the
superiority of eGFR formulas. Methods: The present study evaluated CKD
in patients undergoing allogeneic HSCT. We analyzed the 94 children who
received allogeneic HSCT at the Ege University in \selectlanguage{polish}İ\selectlanguage{english}zmir between 2019
August and 2019 November. The patients were evaluated at least 2 years
after transplantation. CKD was defined as a glomerular filtration rate
(GFR)\textless{}90 mL/min/1.73 m2, using eGFR equations which are based
on serum creatinine (SCr), cystatin C (CysC), and SCr plus CysC.
Results: In our study, 9 (9.4\%) according to Bedside Schwartz, 59
(76.6\%) according to CKiD-eGFR-CysC and 20 (26\%) patients according to
CKiD-eGFR-SCr-CysC equation were evaluated as CKD. In cases evaluated as
CKD according to CysC, early development of acute kidney injury (AKI),
posttransplant cytomegalovirus (CMV) reactivation and being
\textgreater{}10 years old during transplantation were found to be
associated with the development of CKD. Conclusion: We may be delayed in
detecting CKD by calculating SCr-based formulas in HSCT cases, which is
a patient group where early diagnosis and treatment of CKD is very
important.%
\end{abstract}%



\sloppy


\textbf{Assessing long-term renal outcome after allogeneic hematopoietic
stem cell transplantation in children with estimated glomerular
filtration rate equations, based on creatinine and cystatin C levels.}

A. Gadashova, MD\textsuperscript{1}, S. Conkar Tun\selectlanguage{ngerman}çay,
MD\textsuperscript{1}, G. Özek, MD\textsuperscript{2}, G.
Hakverdi,MD\textsuperscript{3}, S. Kansoy, MD\textsuperscript{2}, C.
Kabasakal, MD\textsuperscript{1}, S. Aksoylar, MD\textsuperscript{2}.

\textsuperscript{1} Ege University Faculty of Medicine, Department of
Pediatric Nephrology, \selectlanguage{polish}İ\selectlanguage{english}zmir, Turkey

\textsuperscript{2} Ege University Faculty of Medicine, Department of
Pediatric Bone Marrow Transplantation, \selectlanguage{polish}İ\selectlanguage{english}zmir, Turkey

\textsuperscript{3} Ege University Faculty of Medicine, Department of
Biostatistics and Medical Informatics \selectlanguage{polish}İ\selectlanguage{english}zmir, Turkey

Aysha Gadashova Ege University Faculty of Medicine, General
Pediatrician, \selectlanguage{polish}İ\selectlanguage{english}zmir, Turkey, Dr. Assistant

Mail: ayshegadashova@gmail.com

Se\selectlanguage{ngerman}çil Conkar Tunçay Ege University Faculty of Medicine, Department of
Pediatric Nephrology, \selectlanguage{polish}İ\selectlanguage{english}zmir, Turkey Dr. Associate Professor

Mail: secil.conkar@ege.edu.tr

Orcid: 0000-0001-9189-0480

G\selectlanguage{ngerman}ülcihan Özek Ege University Faculty of Medicine, Department of
Pediatric Bone Marrow Transplantation, \selectlanguage{polish}İ\selectlanguage{english}zmir, Turkey, Dr. Associate
Professor

Mail:gulcihanozek@yahoo.com

G\selectlanguage{ngerman}ülden Hakverdi Ege University Faculty of Medicine, Department of
Biostatistics and Medical Informatics \selectlanguage{polish}İ\selectlanguage{english}zmir, Turkey

Mail: g.hakverdi1706@hotmail.com

Orcid:000-0002-8078-0451

Sava\selectlanguage{polish}ş \selectlanguage{english}Kansoy Ege University Faculty of Medicine, Department of Pediatric
Bone Marrow Transplantation, \selectlanguage{polish}İ\selectlanguage{english}zmir, Turkey, Dr. Professor

Mail: savaskansoy@gmail.com

Caner Kabasakal Ege University Faculty of Medicine, Department of
Pediatric Nephrology, \selectlanguage{polish}İ\selectlanguage{english}zmir, Turkey Dr. Professor

Mail caner.kabasakal@gmail.com

Serap Aksoylar Ege University Faculty of Medicine, Department of
Pediatric Bone Marrow Transplantation, \selectlanguage{polish}İ\selectlanguage{english}zmir, Turkey, Dr.Professor

Mail: serap.aksoylar@gmail.com

Correspondence to:

Se\selectlanguage{ngerman}çil Conkar Tunçay, MD, Ege University School of Medicine, Department
of Pediatric Nephrology, Associate Professor, \selectlanguage{polish}İ\selectlanguage{english}zmir 3500, Turkey.Tel:
+90 554 539 0501,Email: secil.conkar@ege.edu.tr

Text word count: 3557

Abstract word count: 221

The short title: allogenic hematopoietic stem cell transplantation

Key words: allo-HSCT, estimated GFR, chronic kidney disease, child,
cystatin C.

The number of Tables: 5

The number of figures: 0

Abbreviations\selectlanguage{english}
\begin{longtable}[]{@{}ll@{}}
\toprule
HSCT & HEMATOPOIETIC STEM CELL TRANSPLANTAT\selectlanguage{polish}İ\selectlanguage{english}ON\tabularnewline
CNI & CALCINEURIN INHIBITORS\tabularnewline
CKD & CHRONIC K\selectlanguage{polish}İ\selectlanguage{english}DNEY DISEASE\tabularnewline
SCr & SERUM CREATININE\tabularnewline
CysC & CYSTATIN C\tabularnewline
eGFR & ESTIMATED GLOMERULAR FILTRATION RATE\tabularnewline
CMV & CYTOMEGALOVIRUS\tabularnewline
AKI & ACUTE KIDNEY INJURY\tabularnewline
TBI & TOTAL BODY IRRADIATION\tabularnewline
VOD & VENO-OCCLUSIVE DISEASE\tabularnewline
GVHD & GRAFT VERSUS HOST DISEASE\tabularnewline
AML & ACUTE MYELOID LEUKEMIA\tabularnewline
ALL & ACUTE LYMPHOBLASTIC LEUKEMIA\tabularnewline
HLH & HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS\tabularnewline
LCH & LANGERHANS CELL HISTIOCYTOSIS\tabularnewline
\bottomrule
\end{longtable}

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\selectlanguage{english}
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