Characteristic Phase 1 (n=50) Phase 3 (n=50) p-value
Male gender 50 46 0.68
Age (years, mean ± SD) 51.9+19.1 48.7+18 0.98
Comorbidities Comorbidities Comorbidities Comorbidities
Diabetes Mellitus 30 38 0.39
Hypertension 34 30 0.66
Asthma 0 2 1.00
COPD 14 22 0.21
CKD 6 14 0.31
CAD 6 18 0.12
CVA 2 8 0.36
APACHE II score* 20.5 + 6.9 23.5 + 6.6 0.02
SOFA score* 8.1 + 3.2 8.2 + 3.2 0.90