REFERENCES
A. M. Shelton, J.-Z. Zhao, Roush RT. 2002. Economic, Ecological, Food
Safety, and Social Consequences of the Deployment of Bt Transgenic
Plants. Annu. Rev. Entomol. 47 :845–881.
Alvarez MA. 2014. The Antibody 14D9 as an Experimental Model for
Molecular Farming. In: . Plant Biotechnol. Heal. Cham: Springer,
pp. 111–131.
Cardon F, Pallisse R, Bardor M, Caron A, Vanier J, Ele Ekouna JP,
Lerouge P, Boitel-Conti M, Guillet M. 2019. Brassica rapa hairy
root based expression system leads to the production of highly
homogenous and reproducible profiles of recombinant human
alpha-L-iduronidase. Plant Biotechnol. J. 17 :505–516.
Dehdashti SM, Acharjee S, Nomani A, Deka M. 2020. Production of
pharmaceutical active recombinant globular adiponectin as a secretory
protein in Withania Somnifera hairy root culture. J. Biotechnol.323 :302–312.
Drake PM, Barbi T, Sexton A, McGowan E, Stadlmann J, Navarre C, Paul MJ,
Ma JK-C. 2009. Development of rhizosecretion as a production system for
recombinant proteins from hydroponic cultivated tobacco. FASEB J.23 :3581–3589.
Drake PMW, Chargelegue DM, Vine ND, Van Dolleweerd CJ, Obregon P, Ma
JKC. 2003. Rhizosecretion of a monoclonal antibody protein complex from
transgenic tobacco roots. Plant Mol. Biol.
Ele Ekouna JP, Boitel-Conti M, Lerouge P, Bardor M, Guerineau F. 2017a.
Enhanced production of recombinant human gastric lipase in turnip hairy
roots. Plant Cell. Tissue Organ Cult. 131 :601–610.
http://dx.doi.org/10.1007/s11240-017-1309-1.
Ele Ekouna JP, Boitel-Conti M, Lerouge P, Bardor M, Guerineau F. 2017b.
Enhanced production of recombinant human gastric lipase in turnip hairy
roots. Plant Cell, Tissue Organ Cult. 131 :601–610.
Fox JL. 2012. First plant-made biologic approved. Nat.
Biotechnol. 30 :472–472.
Fraissinet-Tachet L, Baltz R, Chong J, Kauffmann S, Fritig B, Saindrenan
P. 1998. Two tobacco genes induced by infection, elicitor and salicylic
acid encode glucosyltransferases acting on phenylpropanoids and benzoic
acid derivatives, including salicylic acid. FEBS Lett.437 :319–323.
Gutierrez-Valdes N, Häkkinen ST, Lemasson C, Guillet M, Oksman-Caldentey
KM, Ritala A, Cardon F. 2020. Hairy Root Cultures—A Versatile Tool
With Multiple Applications. Front. Plant Sci.
Häkkinen ST, Raven N, Henquet M, Laukkanen ML, Anderlei T, Pitkänen JP,
Twyman RM, Bosch D, Oksman-Caldentey KM, Schillberg S, Ritala A. 2014.
Molecular farming in tobacco hairy roots by triggering the secretion of
a pharmaceutical antibody. Biotechnol. Bioeng. 111 .
Häkkinen ST, Reuter L, Nuorti N, Joensuu JJ, Rischer H, Ritala A. 2018.
Tobacco BY-2 media component optimization for a cost-efficient
recombinant protein production. Front. Plant Sci. 9 .
Häkkinen ST, Moyano E, Cusidó RM, Palazó J, Teresa M, Ol P,
Oksman-Caldentey K-M. 2005. Enhanced secretion of tropane alkaloids in
Nicotiana tabacum hairy roots expressing heterologous
hyoscyamine-6b-hydroxylase. J. Exp. Bot. 56 :2611–2618.
Halder M, Sarkar S, Jha S. 2019. Elicitation: A biotechnological tool
for enhanced production of secondary metabolites in hairy root cultures.Eng. Life Sci. 19 :880–895.
He X, Haselhorst T, von Itzstein M, Kolarich D, Packer NH, Gloster TM,
Vocadlo DJ, Clarke LA, Qian Y, Kermode AR. 2012. Production of
α-L-iduronidase in maize for the potential treatment of a human
lysosomal storage disease. Nat. Commun. 2012 31 3 :1–9.
Holland T, Sack M, Rademacher T, Schmale K, Altmann F, Stadlmann J,
Fischer R, Hellwig S. 2010. Optimal nitrogen supply as a key to
increased and sustained production of a monoclonal full-size antibody in
BY-2 suspension culture. Biotechnol. Bioeng.107 :278–289.
Huet Y, Ele J-P, Aurore E, Katiba C, Michèle Boitel-Conti M, Guerineau
F. 2014. Production and secretion of a heterologous protein by turnip
hairy roots with superiority over tobacco hairy roots. Biotechnol.
Lett. 36 :181–190.
Karimzadegan V, Jalali Javaran V, Shams Bakhsh M, Jalali Javaran M.
2019. The Effect of Methyl Jasmonate and Temperature on the Transient
Expression of Recombinant Proteins in Cucurbita pepo L. Mol.
Biotechnol. 61 :84–92.
LaCount W, An G, Lee JM. 1997. The effect of polyvinylpyrrolidone (PVP)
on the heavy chain monoclonal antibody production from plant suspension
cultures. Biotechnol. Lett. 19 :93–96.
Lucht JM. 2015. Public Acceptance of Plant Biotechnology and GM Crops.Viruses 7 :4254–4281.
Madeira LM, Szeto TH, Henquet M, Raven N, Runions J, Huddleston J,
Garrard I, Drake PMW, Ma JK-C. 2016. High-yield production of a human
monoclonal IgG by rhizosecretion in hydroponic tobacco cultures.Plant Biotechnol. J. 14 :615–624.
Magnuson NS, Linzmaier PM, Gao JW, Reeves R, An G, Lee JM. 1996.
Enhanced recovery of a secreted mammalian protein from suspension
culture of genetically modified tobacco cells. Protein Expr.
Purif. 7 :220–228.
Martínez C, Petruccelli S, Giulietti AM, Alvarez MA. 2005. Expression of
the antibody 14D9 in Nicotiana tabacum hairy roots. Electron. J.
Biotechnol. 8 :51–57.
Medicago. 2021. Medicago and GSK announce positive Phase 3 efficacy and
safety results for adjuvanted plant-based COVID-19 vaccine candidate.
https://www.gsk.com/en-gb/media/press-releases/med.
Oksman-Caldentey K-M, Kivela O, Hiltunen R. 1991. Spontaneous shoot
organogenesis and plant regeneration from hairy root cultures of
Hyoscyamus muticus. Plant Sci. 78 :128–136.
Pham NB, Schäfer H, Wink M. 2012. Production and secretion of
recombinant thaumatin in tobacco hairy root cultures. Biotechnol.
J. 7 :537–545.
Rage E, Marusic C, Lico C, Salzano AM, Scaloni A, Baschieri S, Donini M.
2020. Optimisation of PD-FcY veterinary antigen secretion from Nicotiana
benthamiana hairy roots and purification from the culture medium.Plant Cell. Tissue Organ Cult. 142 :23–39.
Rini Vijayan KP, Raghu A V. 2020. Methods for Enhanced Production of
Metabolites Under In Vitro Conditions. Plant Metab. Methods, Appl.
Prospect. :111–140.
Scheible W-R, Morcuende R, Czechowski T, Fritz C, Osuna D,
Palacios-Rojas N, Schindelasch D, Thimm O, Udvardi MK, Stitt M. 2004.
Genome-Wide Reprogramming of Primary and Secondary Metabolism, Protein
Synthesis, Cellular Growth Processes, and the Regulatory Infrastructure
of Arabidopsis in Response to Nitrogen. Plant Physiol.136 :2483–2499.
Sharp JM, Doran PM. 2001. Strategies for enhancing monoclonal antibody
accumulation in plant cell and organ cultures. Biotechnol. Prog.17 :979–992.
Taiz L. 1994. Expansins: Proteins that promote cell wall loosening in
plants. Proc. Natl. Acad. Sci. U. S. A. 91 :7387–7389.
U.S. National Library of Medicine. 2022. Search of: plant-derived AND
pharmaceuticals - Results on Map - ClinicalTrials.gov.
Vasilev N, Schmitz C, Dong L, Ritala A, Imseng N, Häkkinen ST, van der
Krol S, Eibl R, Oksman-Caldentey KM, Bouwmeester H, Fischer R,
Schillberg S. 2014. Comparison of plant-based expression platforms for
the heterologous production of geraniol. Plant Cell. Tissue Organ
Cult. 117 .
Wongsamuth R, Doran PM. 1997. Production of monoclonal antibodies by
tobacco hairy roots. Biotechnol. Bioeng. 54 :401–415.