Statistical Analysis
Categorical variables were expressed as numbers and percentages.
Continuous variables were expressed as mean (±SD) when normally
distributed, otherwise as median [IQR]. ROTEM variables were
visualized using box plots. ROTEM reference values are illustrated as
dashed lines and shaded areas and are based on reference ranges by Lang
et al 20. Proportions were compared using the
chi-square test. Fisher’s exact test was used when the number of cases
was less than 5, and continuous variables were evaluated using the
Mann-Whitney test. Wilcoxon signed-rank test was used for analyzing
related samples. Missing values were not analyzed. A p -value
< 0.05 was considered statistically significant and analyses
were performed using standard software (IBM Corp. Released 2019. IBM
SPSS Statistics, Version 26. Armonk, NY: IBM Corp).