Statistical Analysis
Categorical variables were expressed as numbers and percentages. Continuous variables were expressed as mean (±SD) when normally distributed, otherwise as median [IQR]. ROTEM variables were visualized using box plots. ROTEM reference values are illustrated as dashed lines and shaded areas and are based on reference ranges by Lang et al 20. Proportions were compared using the chi-square test. Fisher’s exact test was used when the number of cases was less than 5, and continuous variables were evaluated using the Mann-Whitney test. Wilcoxon signed-rank test was used for analyzing related samples. Missing values were not analyzed. A p -value < 0.05 was considered statistically significant and analyses were performed using standard software (IBM Corp. Released 2019. IBM SPSS Statistics, Version 26. Armonk, NY: IBM Corp).