Patients with a high BMI
It is proven that the dose of heparin calculated with actual body weight
(in our case) as compared to the ideal body weight would lead to
overdose of heparin thereby increasing the risk of heparin rebound and
bleeding (1/7). We hypothesized that protamine infusion might have
better outcomes in this group.
Our study included 278 patients with high BMI (defined as BMI ≥30), 203
of them received protamine infusion. We could not demonstrate
statistically significant difference in total drainage, blood
transfusion, FFP, or indexed blood loss in the two groups. Platelets
transfusion was significantly less in patients who received protamine
(0.11 unit / patient vs 0.27) P value was 0.023. (Table 2)