The main finding of this study was that approximately half of those with IgE sensitization to shrimp were also sensitized to mites, and vice versa. We also found that participants who were sensitized to both shrimp and mites were more likely to have respiratory symptoms, angioedema, and airflow limitation. Our results suggest that patients presenting symptoms of shrimp or mite allergy should be examined for sensitization and allergy to both allergens. These results are also relevant when introducing new food products, such as insect-based foods, on the market, since insects express the muscle protein tropomyosin, which is similar to the tropomyosin allergens found in shrimp and mites.