Figure 5: Representation of the energy minimized models of IRX4 homeodomain bound to DNA generated using UCSF Chimera . Arginine on the N-terminal of the homeodomain on both the monomers binds to the minor grove of DNA, highlighting the importance of arginines in this complex. Additional residues in the helix, including T191, A194, N196, R198, R199 bound to DNA. Red and yellow are the two strands of DNA. The dotted lines represent the interactions between amino acids and DNA bases. (coloured from blue to red represents N- to C-terminus of protein)