Abstract
We report the first case series of
14 children with intracranial germ cell tumour (iGCT) and concomitant
central diabetes insipidus (DI), who developed hyponatremia secondary to
renal salt wasting syndrome (RSWS) following the administration of
carboplatin. Clinicians prescribing platinum-based chemotherapy for this
group of patients should be alert to the risk of RSWS. Regular
monitoring should be performed as hyponatraemia can be asymptomatic
until it is severe.