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\begin{document}

\title{Optimizing nanoencapsulation of Heracleum Lasiopetalum by response
surface methodology}



\author[1]{Mahsa Yazdan-Bakhsh}%
\author[1]{Mojtaba Nasr-Esfahani}%
\author[1]{reza esmaeilzadeh kenari}%
\author[1]{Mohamad Fazel-Najafabadi}%
\affil[1]{Affiliation not available}%


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  \date{May 26, 2024}


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\begin{abstract}
This study was carried out to optimize formulation for Heracleum
Lasiopetalum (golpar) extract nanoencapsulation by response surface
methodology (RSM). The primary emulsion was fabricated by (5-10 \%)
golpar extract (GE), (40-35 \%) emulsifier span 80 (EM), and (50-60 \%)
sunflower oil (SO). The coating materials of nanoencapsulation were the
composition of Lepidium sativum seed gum (LSG) and whey protein
concentrate (WPC) at different ratios (1:0, 1:1, and 0:1). The yield of
nanoencapsulation of golpar extract, particle size, and zeta potential
was investigated as responses of RSM. The optimal formulation for
nanoencapsulation of golpar extract were SO: 50.46\%, GE 9.52\%, and EM:
36.30\% in LSG, SO: 57.07\%, GE: 7.12\%, and EM: 30.85\% in LSG:WPC, and
SO: 54.98\%, GE: 9.05\%, and EM: 39.87\% in WPC coating. In conclusion,
the nanoencapsulation of golpar extract prepared with the optimized
formulation by RSM ensures the gradual release and sedimentation during
storage with nanometric size and high yield of encapsulation. The
nanocapsules of golpar extract can be used as a natural antioxidant in
food systems.%
\end{abstract}%



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\textbf{Hosted file}

\verb`Manuscript2.docx`  available at \url{https://authorea.com/users/451173/articles/549398-optimizing-nanoencapsulation-of-heracleum-lasiopetalum-by-response-surface-methodology}

\textbf{Hosted file}

\verb`Reviewer.docx`  available at \url{https://authorea.com/users/451173/articles/549398-optimizing-nanoencapsulation-of-heracleum-lasiopetalum-by-response-surface-methodology}

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