AUTHOR CONTRIBUTIONS
X.H., X.C., Y.L., B.J.W and R.H.F. conceived and designed the experiments. Y.L., X.C. and V.A.P. generated and analyzed sequencing data. X.H., X.C., R.M.C., P.A.P.R and M.K performed cell-based functional analysis. W.Y., G.M.S., L.L.W., A.R., M.E.R., and R.H.F. identified NTD cases and acquired clinical data. X.H., X.C., Y.L., and R.H.F. drafted the manuscript, and all other authors assisted in editing.