AUTHOR CONTRIBUTIONS
X.H., X.C., Y.L., B.J.W and R.H.F. conceived and designed the
experiments. Y.L., X.C. and V.A.P. generated and analyzed sequencing
data. X.H., X.C., R.M.C., P.A.P.R and M.K performed cell-based
functional analysis. W.Y., G.M.S., L.L.W., A.R., M.E.R., and R.H.F.
identified NTD cases and acquired clinical data. X.H., X.C., Y.L., and
R.H.F. drafted the manuscript, and all other authors assisted in
editing.