Multidrug efflux pumps are overrepresented among the CORFs with the highest Tajima’s D values
The CORFs displaying the highest Tajima’s D values also included multidrug efflux pump subunits from bacterial species other thanBacteroides dorei , including Bacteroides eggerthii ,Bacteroides fragilis , Coprobacter fastidiosus ,Bifidobacterium breve , and others (Figure 2, Table S1). Post-hoc Fischer’s exact tests were employed to test whether ORFs coding for peptides that belong to multidrug efflux pump complexes were significantly overrepresented among the ORFs with Tajima’s D values >3. A total of 329 CORFs displayed Tajima’s values >3, and these included 9 CORFs coding for components of multidrug efflux pumps. In contrast, only 3,692 of the total 566,985 CORFs were annotated as coding for components of multidrug efflux pumps. These analyses indicated that CORFs coding for components of multidrug efflux pumps were significantly overrepresented among the ORFs with Tajima’s D values >3 (Fisher’s exact test, p -value = 4e-4).