Figure 3 Contribution of peripheral-located Cav3.2 channels in inflammatory pain
Mechanical allodynia (left ) and mechanical hyperalgesia (right ) were assessed in Cav3.2Nav1.8 cKO mice and their control littermates (Cav3.2GFP-floxKI) receiving either an intraplantar injection of carrageenan (A ) or intraarticular CFA (B ). Mice were submitted to the von Frey test to assess mechanical allodynia (left ) and hyperalgesia (right ). Statistical differences were assessed by two-way ANOVA (Time, Genotype or Treatments) followed by Bonferroni post-hoc test [significant differences between Cav3.2Nav1.8 cKO and Cav3.2GFP-flox KI group are indicated by asterisks (*p < 0.05; **p < 0.01; ***p < 0.001)]. Data represent mean ± SEM.