Cav3.2 calcium channels involvement in inflammation and related pain-like symptoms in murine inflammatory models
Elodie Picard (PhD)1,2,6†, Nicolas Kerckhove (PhD)1,2,5†, Amaury François (PhD)3, Ludivine Boudieu (PhD)1,2, Elisabeth Billard (PhD)4, Frédéric Antonio Carvalho (PhD)1,2, Gemma Bogard (PhD student)6, Philippe Gosset (PhD)6, Justine Bourdier (BSc)1,2, Youssef Aissouni (PhD)1,2, Emmanuel Bourinet (PhD)3, Alain Eschalier (MD, PhD)1,2, Laurence Daulhac (PhD)1,2, Christophe Mallet (PhD)1,2*
1 Université Clermont Auvergne, Inserm, U1107 Neuro-Dol, Pharmacologie Fondamentale et Clinique de la Douleur, Clermont-Ferrand, France.
2 ANALGESIA Institute, Faculty of Medicine, Clermont-Ferrand, France.
3 IGF, Université de Montpellier, CNRS, INSERM, Montpellier, France.
4 Université Clermont Auvergne, Inserm U1071, INRA USC2018, M2iSH, Clermont–Ferrand, France.
5 University Hospital of Clermont-Ferrand, Medical Pharmacology Department, Clermont-Ferrand, France.
6 University of Lille, Inserm, U1019, CNRS UMR 9017, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
Drs Picard and Kerckhove contributed equally to the work.
Correspondence : Christophe Mallet, Inserm, Université Clermont Auvergne, U1107 Neuro-Dol, Pharmacologie Fondamentale et Clinique de la Douleur, F-63000 Clermont-Ferrand, France; christophe.mallet@uca.fr; Phone: + 33 4 73 17 81 03.
Running title: Role of Cav3.2 calcium channels in inflammation and related pain
Keywords: T-type calcium channels; inflammatory pain; inflammation; mechanical hypersensitivity; pharmacology
Funding: This work was supported by Agence Nationale de la Recherche (ANR-15-CE16-0012-01, LABEX ICST, “Investissements d’Avenir” program I-Site CAP 20-25), FRM (équipe FRM 2015) grants and Inserm, CNRS, Clermont Auvergne and Montpellier Universities. Nicolas Kerckhove was supported by fellowships from the European Fund for Regional Economic Development (FEDER), the regional council of Auvergne-Rhône-Alpes (“Pack Ambition Recherche 2021”) and the “Société Française d’Etude et de Traitement de la Douleur” (SFETD).