Measurement and change at second time point.
At the second time point, most measurements were within the normal range, except for the atrial width (p<0.003), the ventricular volume (p=0.024) and the extra-axial space volume (p=0.005), which were larger than normal. The total brain cortical grading was lower than normal (p=0.011), on both sides (p=0.019 and p=0.035), and the opercularization was within the normal range (p>0.05). (Figure 4) The Sylvian fissure depth was deeper (both p<0.003) but all other fissures were comparable with controls . Compared to findings on initial scans, the atrial width increased further, the brain fissures which were initially less deep, measured within the normal range. The depth of the Sylvian fissure, which was normal earlier on, became abnormally deeper; also the left brain hemisphere cortical grading score was abnormal, but significantly less than at the first time point. Although the difference in brain scoring between the CDH population and the controls was smaller at the second time point, this was not significantly different from the first time point. (table S2)