Conclusion
In conclusion, we report delayed brain development in CDH fetuses around 28 weeks, which becomes less prominent at 33 weeks. This mandates further investigation into the sulcation pattern beyond 34 weeks in CDH fetuses, including quantitative methods, e.g. cortical folding pattern analysis36, cortical thickness, local gyrification index25, as well as earlier in fetuses not undergoing fetal therapy. We also observed an increase in extra-axial space and also in ventricular volume in the third trimester. Of note is that there was no correlation between brain development and the severity of lung hypoplasia in this highly selected group.