Measurement at first time point.
The biometry of the fetal brain (BPD, FOD and TCD) and skull (BPD and
FOD) was not different between fetuses with CDH and those without. The
extra axial space and atrial width in CDH fetuses were within the normal
range, except for one fetus having mild ventriculomegaly (11 mm). The
total brain cortical grading for fetuses with CDH was significantly
lower than in controls (p<0.003). (Figure 3) When comparing
the brain grading of each hemisphere, the difference was present on both
sides (both p<0.003). The opercularization was delayed on the
left side (p=0.011), but not on the right (p=0.057). There was a reduced
depth of the parieto-occipital fissure (p<0.003 on the right
and p=0.003 on the left), cingulate fissure (left and right
p<0.003) but the depth of the calcarine fissure was normal on
both sides (p>0.05) compared with controls. The Sylvian
fissure was only just significantly deeper on the right (p=0.042), but
not on the left (p=0.055) in fetuses with CDH. The insular depth in
fetuses with CDH was within the normal range (p>0.05).
There was no difference in volume of the total skull, extra-axial space,
ventricular system, white matter or cerebellum between CDH fetuses and
normal controls. (table S2)