Tables and figures
Figure 1: T2- weighted images of the fetal brain in the coronal
(A, B) and sagittal plane (C). Transverse cerebellar diameter (black
line in A) and atrial width (white line in A) are shown. In B the
biparietal diameter of the brain (white line) and the skull (black line)
are illustrated. The fronto-occipital diameter of the brain (white line
in C) and skull (black line in C) is measured as demonstrated.
Table 1: General characteristics of the congenital
diaphragmatic hernia cohort.
Figure 2: T2-weighted images in the axial (A), coronal (B) and
sagittal (C) plane illustrating automated segmentations of the
extra-axial space (yellow), white matter (red), ventricular system
(green) and cerebellum (blue).
Figure 3: Graphs demonstrating the observations in the normal
population (black triangles) and CDH cohort at the first time point
(white circles) of the total skull volume, total brain grading,
extra-axial space volume, cerebellar volume, atrial width and
ventricular volume. The trend line of the controls (full black line) and
CDH population at time point 1 (dashed black line) is shown. The
provided p-value is the significance level of the Wilcoxon-Mann-Whitney
test. The 95% confidence interval (red lines) is also shown.
Figure 4: Graphs demonstrating the paired observations of the
total skull volume, total brain grading, extra-axial space volume,
cerebellar volume, atrial width and ventricular volume. The provided
p-value is the significance level of the Wilcoxon-Mann-Whitney test
comparing the observations at the second time point in fetuses with
congenital diaphragmatic hernia compared to normal controls. The mean
value of the control populations (full line) with the 95% confidence
interval (dashed line) are also shown.
Table S1: Overview of indications for scanning the normal
cohort.
Table S2: Number of fetuses available, mean and standard
deviation and respective p-values of the Wilcoxon-Mann-Whitney test
performed between the normal controls and fetuses with CDH at time point
1 and 2 respectively as well as of the Wilcoxon hypothesis test of the
difference between time point 2 and 1.