Tables and figures
Figure 1: T2- weighted images of the fetal brain in the coronal (A, B) and sagittal plane (C). Transverse cerebellar diameter (black line in A) and atrial width (white line in A) are shown. In B the biparietal diameter of the brain (white line) and the skull (black line) are illustrated. The fronto-occipital diameter of the brain (white line in C) and skull (black line in C) is measured as demonstrated.
Table 1: General characteristics of the congenital diaphragmatic hernia cohort.
Figure 2: T2-weighted images in the axial (A), coronal (B) and sagittal (C) plane illustrating automated segmentations of the extra-axial space (yellow), white matter (red), ventricular system (green) and cerebellum (blue).
Figure 3: Graphs demonstrating the observations in the normal population (black triangles) and CDH cohort at the first time point (white circles) of the total skull volume, total brain grading, extra-axial space volume, cerebellar volume, atrial width and ventricular volume. The trend line of the controls (full black line) and CDH population at time point 1 (dashed black line) is shown. The provided p-value is the significance level of the Wilcoxon-Mann-Whitney test. The 95% confidence interval (red lines) is also shown.
Figure 4: Graphs demonstrating the paired observations of the total skull volume, total brain grading, extra-axial space volume, cerebellar volume, atrial width and ventricular volume. The provided p-value is the significance level of the Wilcoxon-Mann-Whitney test comparing the observations at the second time point in fetuses with congenital diaphragmatic hernia compared to normal controls. The mean value of the control populations (full line) with the 95% confidence interval (dashed line) are also shown.
Table S1: Overview of indications for scanning the normal cohort.
Table S2: Number of fetuses available, mean and standard deviation and respective p-values of the Wilcoxon-Mann-Whitney test performed between the normal controls and fetuses with CDH at time point 1 and 2 respectively as well as of the Wilcoxon hypothesis test of the difference between time point 2 and 1.