Measurement and change at second time point.
At the second time point, most measurements were within the normal
range, except for the atrial width (p<0.003), the ventricular
volume (p=0.024) and the extra-axial space volume (p=0.005), which were
larger than normal. The total brain cortical grading was lower than
normal (p=0.011), on both sides (p=0.019 and p=0.035), and the
opercularization was within the normal range (p>0.05).
(Figure 4) The Sylvian fissure depth was deeper (both p<0.003)
but all other fissures were comparable with controls . Compared to
findings on initial scans, the atrial width increased further, the brain
fissures which were initially less deep, measured within the normal
range. The depth of the Sylvian fissure, which was normal earlier on,
became abnormally deeper; also the left brain hemisphere cortical
grading score was abnormal, but significantly less than at the first
time point. Although the difference in brain scoring between the CDH
population and the controls was smaller at the second time point, this
was not significantly different from the first time point. (table S2)