Adrenal insufficiency
Adrenal insufficiency (AI) is characterized by insufficient
glucocorticoid and mineralocorticoid secretion and requires replacement
therapy with hydrocortisone and fludrocortisone. Several reviews
concluded that AI patients exhibited impaired physical and mental health
as well as increased psychopathology independent of the aetiology of AI
(Hahner et al. , 2021). Importantly, several studies have shown
that psychopathology, cognition, and quality of life depend on
hydrocortisone treatment regimens that closely mimic physiological
cortisol secretion and on sufficient MR activation through
fludrocortisone (Øksnes et al. , 2014; Schultebraucks K,
Wingenfeld K, Otte C, 2016). The (interdependent) contributions of MR
and GR to these psychopathological symptoms remain however undefined.